Acridine derivatives activate p53 and induce tumor cell death through bax
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چکیده
منابع مشابه
An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes
Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present study aimed to evaluate the effect of 5-Aza-CdR on the proliferation of human pancreatic cancer ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2005
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.4.8.2134